Julia Louis-Dreyfus was honoured with the Mark Twain Prize for lifetime achievement in comedy on Sunday, and she accepted her award with an extended comedic bit and a few shots at new Supreme Court Justice Brett Kavanaugh.

The veteran comedic actress first drew laughs by repeatedly referencing her true life’s ambition to be a respected dramatic actress. Mid-speech, she stopped to deliver a monologue from Shakespeare’s Merchant of Venice.

A native of Washington suburbs in Maryland, Louis-Dreyfus is a graduate of the elite Holton-Arms School. It’s also the alma mater of Dr Christine Blasey Ford, who accused Kavanaugh of groping her in high school.

Louis-Dreyfus make a veiled but unmistakable reference to Ford’s testimony, as she recalled a high school performance of the play Serendipity. “I can remember every single aspect of that play that night, so much so that I would testify under oath about it. But I can’t remember who drove me there or who drove me home.”

After a 35-year acting career and with two iconic television characters to her name — Elaine Benes of Seinfeld and foul-mouthed Vice-President Selina Meyer of Veep — the 57-year-old actress received a stream of testimonials from celebrities, including Jerry Seinfeld, Stephen Colbert and 2010 Mark Twain recipient Tina Fey, touching on the multiple aspects of her career.

Tina Fey arrives at the Kennedy Center for the Performing Arts for the 21st Annual Mark Twain Prize for American Humor. AP

Fey paid tribute to Louis-Dreyfus at the award ceremony, held at Washington’s Kennedy Center by tracking the similarities between their lives. “We both started comedy in Chicago. We both moved on to Saturday Night Live. We both lost our virginity to Brad Hall,” Fey said, referring to Louis-Dreyfus’s husband and former SNL cast mate sitting next to the honoree.

Fey praised the “secret precision” of Louis-Dreyfus’s comedy and her willingness to make her Seinfeld character so flawed.

“Julia let Elaine be selfish and petty and sarcastic and a terrible, terrible dancer,” Fey said. “Julia’s never been afraid to be unlikable — not on screen and not in person.”

Louis-Dreyfus is the 21st Mark Twain recipient, joining a list that includes Richard Pryor, George Carlin and Carol Burnett. Bill Cosby, the winner in 2009, had his award rescinded earlier this year after he was convicted of three counts of aggravated indecent assault.

During last year’s ceremony to honour David Letterman, Cosby’s name was never mentioned. But this year, two of the performers felt comfortable making Cosby jokes. Late night, host Stephen Colbert displayed a sign proclaiming, “167 days since the last Un-Twaining”.

With his fingers crossed, he told Louis-Dreyfus, “I think you'll be OK.”

Julia Louis-Dreyfus is honoured with the Mark Twain Prize for American Humor at the Kennedy Center for the Performing Arts on Sunday. AP

Later, Keegan-Michael Key come onstage, dressed as Mark Twain himself and proceeded to roast many of the previous award recipients. When a picture of Cosby was briefly shown, Michael-Key quickly moved things along and said, “It’s OK, he’s not watching,” then added that he doubted PBS was a popular channel “in the penitentiary”.

Seinfeld, while on the red carpet before the ceremony, recalled first meeting Louis-Dreyfus during an informal audition. His iconic sitcom, Seinfeld, was still in the planning stages and producer Larry David knew Louis-Dreyfus from their time together on Saturday Night Live.

“We had just two short pages of script, and we sat down to read the dialogue together,” Seinfeld said. “As soon as she opened her mouth, I knew she was the one.”

Seinfeld also credited Louis-Dreyfus for having the confidence and strength of personality to hold her own on what he called “a very male show”.

Jerry Seinfeild at the award show. AP

That confidence was evident very early for Louis-Dreyfus, who said she knew as a young child that she had a gift for comedy.

“The first time I really knew was when I stuffed raisins in my nose and my mother laughed. I ended up in the emergency room because they wouldn't come out!” Louis-Dreyfus said before the ceremony.

Comedian Kumail Nanjiani grew up in Pakistan and never saw an episode of Seinfeld until he immigrated to the US as an adult. “But I became a huge fan as soon as I moved here,” he said.

Kumail Nanjiani and his wife, Emily Gordon, arrive at the Kennedy Center for the Performing Arts. AP

The co-writer of the movie The Big Sick particularly recalls her iconic, slightly convulsive Elaine Benes dance on the show, which he credits to Louis-Dreyfus’s gift for physical comedy.

“There are some comedians who think physical comedy is beneath them,” he said. “But she was just fearless and ego-less.”

Louis-Dreyfus emerged from Chicago’s famed Second City comedy troupe before joining the cast of Saturday Night Live. Her best-known role is her nine-year run as Elaine Benes on Seinfeld. More recently, her work as Vice-President Selina Meyer on Veep earned her six consecutive Emmy Awards.

Production on the upcoming seventh and final season of Veep was delayed as Louis-Dreyfus received treatment for breast cancer. That season is currently in production.